This is a bit of a weird question. Do you mean if MonoGame offers some classes to help you with keyframe animations or if it's possible to implement on top of MonoGame?
MonoGame doesn't have much for animation out of the box, but you can implement pretty much anything on top of it. It just abstracts some of the low-level and platform-specific details.
There are a bunch of engines and extensions around for MonoGame and I think they most of them support key frame animations one way or another. So if you don't want to implement it yourself have a look at some of those. E.g. MonoGame.Extended or Nez