There was a lot of evidence for yourself that i totally didnāt know thatās why answered what i said.
Making assumption of what other people know leads to misunderstanding 
So :
I never use a VM in my life i know nothing about it.
About 4.5 .NET, my project is running with 4.5 why should i need to add 4.5+ versions ?
I donāt know how to do that for now.
I can see in the prerequisites that i can add in addition to .NET framework, somthing named : Microsoft Report Viewer 2012 Runtime. Is it the thing your talking about ?
Probably, I cannot recall it right now but might look for it again in futureā¦ not going to look through my 1471 page tome right now for it 
Note: Windows 8 and Windows Server 2012 include the .NET Framework 4.5. Therefore, you donāt have to install this software on those operating systems.
https://www.microsoft.com/en-us/download/details.aspx?id=30653
Hunted through my book and found it for youā¦
Specifically:
Prerequisites Dialog Box
This dialog box specifies which prerequisite components are installed, as well as how they are installed. For more information, see How to: Install Prerequisites with a ClickOnce Application and Prerequisites Dialog Box.
Hope that helps.
In fact i just noticed that the game launch but just for a few seconds in task manager. Then it stops
Did you profile your activity? memory usage? what are you doing on launch? are you loading in a lot of objects from disk? do they have enough RAM?
I donāt really profile activity, and i am pretty sure it is not a mistake from memory usage (one tester have 16Gb or memory and he canāt play the game and i ahve only 4 and i play it well)
I donāt think itās a problem related to performance.
Well, i am forced to update to windows 10 to see errors while building, i donāt see another better solution. Damn i really donāt wanted to to that.
I hope the version is not going to work and will generate the expected problem to help me solving it.
I really cannot see any reason to not already be using Windows 10 aside from the minute list of concerns or issues reported by a handful of peopleā¦ Come join the other 400,000,000+ of us happily using it already. 
http://news.microsoft.com/bythenumbers/
Anh ! Youāre a microsoft agent ! Damn i have to run away !!
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Hahahahahahaha Too late, I own your Mouse Pad now! Muahahahahaha
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OMG, the build wasnāt working at first on my Windows 10.
then i built it in VS on my new W10 system and then the game works fine now on my new system without any problem.
I have changed absolutely nothing in the project.
BUT now i tried the exact same working build on another windows 10 system/computer : i see the game running in task manager, going up to almost 500 Mb use of memory then stop to run without any reason.
I am going insane ā¦ HELP !
Do I have to repeat myself? 
How can i share the diagnostic here ?
Sorry but i canāt find how to share it like an image instead of this : http://repstyleart.com/visumeca/Pharmakon161128_TypeSummary.csv
Is it enough ?
What is that? 1MB csv? can you take a snapshot image of it?
I never did a diagnostic like i suppose you are expecting for, can you tell me what i have to do in VS to give you the best stats in order to help me please ?
Like what menu should i choose to show to you what you want ?
I donāt know what you are using but when I debug an app VS displays usage metricsā¦ which VS are you using?
I am using VS2015 Community Edition
I am using VS 2015 Community too
I will leave this for someone else who can assist you betterā¦
Ok my big bad on this one, it seems that i mistaken a bit OpenTK / OpenGL and OpenAL.
Also, the openal.dll i placed in my folder didnāt do their work properly.
So the only way to solve my issue was to use the oalinst (setup file) from https://www.openal.org/downloads/oalinst.zip
Sorry for all the work you did to help.
With all of this, i learnt useful things. Thanks again.
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Failure is the road to success 
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