It depends, and sorry if its a none answer.
But that’s a fact. For the most part it depends on what you are trying to do and how you do your drawing.
If you want to do some Sprite base drawing to a RenderTarget2D then later do some model draws to another render target then at the end do some more sprite base drawing for GUI then yes you can do it with little hassle.Just at the end render the 2 or more layers over each other to a final screen or render target. Remember that there is no true difference between Sprite drawing and 3D model drawing, Geometry with textures is the life of the GPU.