I have an Alienware 15 R3 and am on Nvidia driver v391.25 with Windows 10 64-bit, the latest BIOS version, and MonoGame 220.127.116.119 on a DesktopGL project. If I update to a newer driver version, I cannot run Debug builds at all for some reason. In VS, the game builds, but the graphics device doesn't seem to initialize and the program exits before I can even see the game window. Furthermore, running the .exe of the Debug build produces the same result.
However, Release builds do work, and I'm not really sure why. Is anyone else having a similar problem or does someone have insight into what might be going on?