Yes. I’ve had similar problems with Win 10 64-bit and Nvidia drivers and so have others. I have yet to figure out a solution and I’ve tried everything (fresh installs of the OS, reinstall monogame, update drivers, etc…)
I’ve got one work around but it is hit and miss for me. I can start the game in debug, GPU doesn’t initialize, I hit stop, and start in debug quickly again… and sometimes it initializes. Really annoying but if I keep attempting to start it in debug, it works occasionally.
I don’t have time to search for all the other posts others have reported but here are a few: