Ouya Gamepad and MonoGame 3.2

Oh… yea… that would do that. You really should change that to:

        protected override void Update(GameTime gameTime)
        {
            var state = GamePad.GetState(PlayerIndex.One);
            if (state.Buttons.Back == ButtonState.Pressed)
            {
                Exit();
            }

            if (state.IsButtonDown(Buttons.Start))
            {
                Debug.Write("Start pressed");
            }
            base.Update(gameTime);
        }

Much better for you in the long run.