While not answering the question, this may shed some light on the follow-up question,…
Vector-based grphics - is Monogame the way to go? - General - Community | MonoGame
But to give a response, show us two works to compare, do you have concept art to showcase? we cannot say yes or no without something to judge…
To really answer the question… Do what fits your art direction… if you need feedback, do ask away but please include something for us to give feedback on.
Not trying to sound harsh, just err, trying to get you to help us, help you 
.
Hope that helps.