Start at the basics to work out that no external factors are blocking, so:
First up, just read this recent thread:
Are you running any third party ransomware protection tools?
Are you using third party antivirus apps?
Are you Admin?
Do you have full access to the folder it is working from?
Which directory are you working from?
Are you sure you are clicking the button? [Ok, I know but still, recently my own clicks have been making me feel sceptical of my own clicks too, lol - HATE YOU YOUTUBE]
Can't think of anything else right now...