In VB and I think c# there is the property TextWidth which you can use to return the pixel width of text so you can decide how to display what you want to say.
Is there anything in Monogame that returns the physical size of text before it’s rendered? Reason, so you know where to put line brakes in paragraphs?
spriteBatch.DrawString(Game1.font1, "Click Play Area To Initiate Particle Reaction", new Vector2(Game1.renderWidth / 2 - Game1.font1.MeasureString("Click Play Area To Initiate Particle Reaction").X / 2, (int)Game1.centre.Y - 200), Color.White);