I am in the process of porting a game from Love2D over to Monogame and I am trying to recreate the same pixelated effect that was achieved using Love2D’s nearest filtering mode. I am currently upscaling using a Transform Matrix and using the PointClamp Sampler State. If you look at the guns in the attached image, you can see the Love2D version has the jagged look I am trying to achieve, while Monogame is smooth.
Just in case, I have also attached some code below so you can get an idea of what I am doing.
        public void SetScreenResolution()
        {
            float tempXScale = (screenResolutionX / baseResolutionX);
            float tempYScale = (screenResolutionY / baseResolutionY);
            matrix = Matrix.CreateScale(tempXScale, tempYScale, 1);
            
        }
       protected override void Draw(GameTime gameTime)
        {
            GraphicsDevice.Clear(Microsoft.Xna.Framework.Color.White);
            // Draw background
            _spriteBatch.Begin(blendState: BlendState.AlphaBlend, sortMode: SpriteSortMode.FrontToBack, samplerState: SamplerState.PointClamp, transformMatrix: matrix);
            gameManager.DrawBackground(_spriteBatch);
            _spriteBatch.End();
            // Splatter
            _spriteBatch.Begin(blendState: multiplyBlendState, sortMode: SpriteSortMode.FrontToBack, samplerState: SamplerState.PointClamp, transformMatrix: matrix);
            gameManager.DrawSplatter(_spriteBatch);
            _spriteBatch.End();
            // Main Draw Loop
            _spriteBatch.Begin(blendState: BlendState.AlphaBlend  , sortMode: SpriteSortMode.FrontToBack, samplerState: SamplerState.PointClamp, transformMatrix: matrix);
            gameManager.Draw(_spriteBatch);
            _spriteBatch.End();
            base.Draw(gameTime);
        }
